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High aspect ratio inertial focusing channels offers high throughput portable devices thatcan remove colloidal-size particles from a continuous media for the preparation of samplesor membranes filtration are in need for point of care operations in a compact andlightweight format. This research attempts to increase concentrating efficiency by studyingparticle behavior in the channel expansion that follows a high aspect ratio inertial focusingchannel. The particle behavior in the channel expansion depends on the geometry of theinertial focusing portion of the channel. The inertial focusing geometries studied were twohigh aspect ratio channels one tall and the other wide and a staged channel. We found thatthe staged inertial focusing devices create one focusing position near the channel wall,which in general had provided the narrowest particle streak. This shows that the stageddevices have greatest potential for high efficiency particle separation. With a straight tallIFD we were able to attain a 16.7 fold increase in particle concentration when starting witha less than 0.1%volume concentration solution and a 6 fold increase the a particle solutionwith an initial concentration of around 1%volume. This shows the viability of using IFDsfor particle separations and given the prior stated information we should be able to achieveeven higher concentration efficiencies by using a staged IFD. IntroductionRecently, much more effort has been directed at making lab equipment more portableand less expensive in order to bring medical testing to the point-of-care(POC). POCoperations must be completely self-sufficient, as opposed to a Centralized testing model, in